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Title:
ORGANIC ACID SALT OF 5,6,7,8-TETRAHYDRO-D-NEOPTERIN AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH07145168
Kind Code:
A
Abstract:

PURPOSE: To obtain a new compound producible in high yield in easily purifiable state having extremely high crystallinity and, accordingly, practically usable as an agent for the treatment of side actions of a cancer-suppressing agent and a carcinostatic agent or an agent for the treatment of diseases relating to active oxygen.

CONSTITUTION: An organic acid salt of the 6R or 6S isomer of 5,6,7,8- tetrahydro-D-neopterin expressed by formula I or formula II e.g. (R)- tetrahydroneopterin.(-)camphorsulfonic acid salt. The compound can be produced by treating 5,6,7,8-tetrahydro-Dneopterin dihydrochloride with an ion exchange resin (preferably a strongly basic ion exchange resin) containing adsorbed organic acid (preferably camphorsulfonic acid, tartaric acid or oxalic acid) to effect the ion exchange, dissolving the produced mixture of 6R isomer and 6S isomer in a mixed solvent consisting of water, alcohol or mineral acid and carrying out fractional crystallization of the compound from the solution.


Inventors:
Waga, Toshiaki
Murayama, Wataru
Application Number:
JP1993000317524
Publication Date:
June 06, 1995
Filing Date:
November 25, 1993
Export Citation:
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Assignee:
ASAHI BREWERIES LTD
TORII YAKUHIN KK
International Classes:
C07D475/04; A61K31/505; A61K31/519; A61P35/00; A61P43/00; C07B57/00; (IPC1-7): C07D475/04; C07B57/00
Attorney, Agent or Firm:
舟橋 榮子