Title:
ガンマ/デルタT細胞を活性化するための有機リン化合物
Document Type and Number:
Japanese Patent JP4607451
Kind Code:
B2
Abstract:
The present invention describes organophosphorus compounds of general formula (I) their preparation and their uses in the activation of gamma/delta T-cells, in the screening of GcpE and LytB enzyme inhibitors and in the prophylaxis and treatment of diseases in humans and animals.
Inventors:
Yommer, hassan
Wolf, Oliver
Altinzicek, Boran
Eberle, Matthias
Martin, Hints
Corus, Anne-Kristin
Reichenberg, Armin
Wiesner, Jochen
Wolf, Oliver
Altinzicek, Boran
Eberle, Matthias
Martin, Hints
Corus, Anne-Kristin
Reichenberg, Armin
Wiesner, Jochen
Application Number:
JP2003515247A
Publication Date:
January 05, 2011
Filing Date:
July 18, 2002
Export Citation:
Assignee:
BIOAGENCY AG
International Classes:
C07F9/113; C12N9/99; A61K31/661; A61K31/662; A61K31/663; A61K31/665; A61P1/00; A61P1/04; A61P11/04; A61P11/06; A61P19/00; A61P19/10; A61P25/00; A61P31/12; A61P37/00; A61P37/08; C07F9/09; C07F9/38; C07F9/40; C07F9/6574; C12P19/38; C12Q1/02
Domestic Patent References:
| JP2005505248A |
Foreign References:
| US5639653 | ||||
| WO1997043437A1 | ||||
| WO2000072022A1 | ||||
| WO2000017233A1 | ||||
| WO2000072022A1 |
Other References:
Belmant, Christian 他,3-Formyl-1-butyl pyrophosphate a novel mycobacterial metabolite-activating human γδ T cells,Journal of Biological Chemistry,1999年,274(45),32079-32084
Tanaka, Yoshimasa 他,Natural and synthetic non-peptide antigens recognized by human γδ T cells,Nature (London),1995年,375(6527),155-8
McClard, Ronald W.; Fujita, Thomas S.; Stremler, Kay E.; Poulter, C. Dale,Novel phosphonylphosphinyl (P-C-P-C-) analogs of biochemically interesting diphosphates. Syntheses and properties of P-C-P-C-, analogs of isopentenyl diphosphate and dimethylallyl diphosphate,Journal of the American Chemical Society,1987年,109(18),5544-5
Jacob, L.; Julia, M.; Pfeiffer, B.; Rolando, C.,Influence of phosphoric ester groups in geranyldiphosphate biosynthesis,Bulletin de la Societe Chimique de France (Nov.-Dec.),1990年,719-33
Sireci, Guido 他,Differential activation of human γδ cells by nonpeptide phosphoantigens,European Journal of Immunology ,2001年,31(5),1628-1635
Belmant, Christian 他,A chemical basis for selective recognition of nonpeptide antigens by human δ T cells,FASEB Journal,2000年,14(12),1669-1670
Davisson, V. Jo 他,Phosphorylation of isoprenoid alcohols,Journal of Organic Chemistry ,1986年,51(25),4768-79
Tanaka, Yoshimasa 他,Natural and synthetic non-peptide antigens recognized by human γδ T cells,Nature (London),1995年,375(6527),155-8
McClard, Ronald W.; Fujita, Thomas S.; Stremler, Kay E.; Poulter, C. Dale,Novel phosphonylphosphinyl (P-C-P-C-) analogs of biochemically interesting diphosphates. Syntheses and properties of P-C-P-C-, analogs of isopentenyl diphosphate and dimethylallyl diphosphate,Journal of the American Chemical Society,1987年,109(18),5544-5
Jacob, L.; Julia, M.; Pfeiffer, B.; Rolando, C.,Influence of phosphoric ester groups in geranyldiphosphate biosynthesis,Bulletin de la Societe Chimique de France (Nov.-Dec.),1990年,719-33
Sireci, Guido 他,Differential activation of human γδ cells by nonpeptide phosphoantigens,European Journal of Immunology ,2001年,31(5),1628-1635
Belmant, Christian 他,A chemical basis for selective recognition of nonpeptide antigens by human δ T cells,FASEB Journal,2000年,14(12),1669-1670
Davisson, V. Jo 他,Phosphorylation of isoprenoid alcohols,Journal of Organic Chemistry ,1986年,51(25),4768-79
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Suzuki Otoya
Fusayuki Saito
Suzuki Otoya