Title:
Ornamentation 2' and the 3'-nucleoside prodrug for the department virus infection medical treatment of a Flavi virus
Document Type and Number:
Japanese Patent JP6069169
Kind Code:
B2
Abstract:
2' and/or 3' prodrugs of 1', 2', 3' or 4'-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
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Inventors:
Jiyan-Pierre Somadosi
Paolo La Cotura
Richard Strawr
Jill Goslan
Paolo La Cotura
Richard Strawr
Jill Goslan
Application Number:
JP2013228381A
Publication Date:
February 01, 2017
Filing Date:
November 01, 2013
Export Citation:
Assignee:
Idenix Pharmaceuticals LLC
Unibercita Detsuri Stoday Day Cagliari
Unibercita Detsuri Stoday Day Cagliari
International Classes:
C07H19/06; C07H19/10; A61K9/20; A61K9/48; A61K31/7056; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K38/00; A61K38/21; A61K45/00; A61P31/14; A61P43/00; C07H19/00; C07H19/04; C07H19/044; C07H19/048; C07H19/052; C07H19/056; C07H19/067; C07H19/12; C07H19/14; C07H19/16; C07H19/167; C07H19/20; C07H19/22; C07H19/23
Domestic Patent References:
| JP2015205885A | ||||
| JP2010280660A |
Foreign References:
| WO2001090121A2 | ||||
| WO2001092282A2 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office