Title:
プロスタグランジンE2アゴニストまたはアンタゴニストであるオルニチン誘導体
Document Type and Number:
Japanese Patent JP2007516950
Kind Code:
A
Abstract:
Ornithine derivatives of the formula (I): wherein X is -CO- or -(CH2)k- (wherein k is 1, 2 or 3); Y is Z-(CH2)n-, and the like; {wherein Z is R1-CO-NR4-, and the like, (wherein R1 is aryl, and the like; and R4 is hydrogen, or lower alkyl); and n is 1, 2, 3, 4, 5 or 6}; R2 is aryl-(lower alkyl), and the like; R3 is -Q-R7, [wherein Q is -CO- or -SO2-, R is heterocyclyl], and the like; and R5 and R6 are independently hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof, which are useful as medicament.
More Like This:
Inventors:
Koji Hattori
Naoaki Fujii
Akira Tanaka
Kenichi Washizuka
Minoru Sakurai
Satoshi Kuroda
Toda Susumu
Yutaka Nakajima
Naoaki Fujii
Akira Tanaka
Kenichi Washizuka
Minoru Sakurai
Satoshi Kuroda
Toda Susumu
Yutaka Nakajima
Application Number:
JP2006520516A
Publication Date:
June 28, 2007
Filing Date:
December 17, 2004
Export Citation:
Assignee:
Astellas Pharma Inc.
International Classes:
C07C271/22; A61K31/195; A61K31/196; A61K31/197; A61K31/216; A61K31/235; A61K31/24; A61K31/341; A61K31/343; A61K31/36; A61K31/381; A61K31/40; A61K31/4025; A61K31/404; A61K31/405; A61K31/41; A61K31/415; A61K31/4164; A61K31/4184; A61K31/421; A61K31/437; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4436; A61K31/4439; A61K31/47; A61K31/472; A61K31/498; A61P7/02; A61P13/12; A61P25/04; A61P25/28; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07C215/16; C07C309/66; C07C323/25; C07C327/30; C07D207/16; C07D209/18; C07D209/42; C07D213/30; C07D213/56; C07D215/12; C07D215/48; C07D215/50; C07D215/54; C07D217/26; C07D231/14; C07D233/90; C07D235/24; C07D241/44; C07D263/42; C07D307/42; C07D307/85; C07D333/16; C07D333/68; C07D333/70; C07D401/12; C07D405/12; C07D407/12; C07D409/12; C07D471/04
Attorney, Agent or Firm:
Kyuichi Ueki
Tadashi Sugakawa
Osamu Futakuchi
Hiroaki Ito
Tadashi Sugakawa
Osamu Futakuchi
Hiroaki Ito