Title:
ORTHO CONDENSED PYRROLE DERIVATIVES AND USE
Document Type and Number:
Japanese Patent JPS60172977
Kind Code:
A
Abstract:
The invention provides novel pyrrole derivatives of formula: (I) in which R'=H, alkyl or phenyl optionally substituted by halogen, alkyl, alkyloxy or alkylthio, Z=0 or S, p=0 or 1, and either A is a heterocyclic ring such that it forms, with pyrrole, a 1H,3H-pyrrolo[1,2-c]thiazole, 2,3-dihydro-1H-pyrrolizine optionally substituted by OH, 5,6,7,8-tetrahydroindolizine, 1,2-dihydro-4H-pyrrolo[1,2-c]-1,3-thiazine, 2,3-dihydropyrrolo[2,1-b]thiazole, 1H,3H-pyrrolo[1,2-c]oxazole, 1,2-dihydro-4H-pyrrolo]1,2-c]-1,3-oxazine or 2,3-dihydropyrrolo[2,1-b]oxazole ring system, n=0 or 1, Het=3-pyridyl or 5-thiazolyl, and (1) either R=H, halogen, alkyl or phenyl optionally substituted by halogen, alkyloxy or alkylthio and Y=alkyl or phenyl optionally substituted by halogen, alkyl, alkyloxy or alkylthio, or Y=-NR1R2 with: either R1=H and R2=unsubstituted alkyl, cycloalkyl (C3-C6), alkenyl (C2-C4), alkynyl (C3-C4), benzyl or phenyl radicals optionally substituted by halogen, alkyl, alkyloxy, alkylthio, CF3 or NO2, or R2=adamantyl, pyridyl or pyridylmethyl, or R1 and R2=both unsubstituted alkyl or R1 and R2 from a 4-phenylpiperazin-1-yl radical the phenyl part of which may be substituted by halogen, alkyl, alkyloxy, alkylthio, CF3 or NO2 (2) or R=halogen, alkyl or phenyl optionally substituted by halogen, alkyloxy or alkylthio, and Y=NH2 or A is a heterocyclic ring such that it forms, with pyrrole, a 2,3-dihydro-1H-pyrrolizine substituted by OH, 2,3-dihydropyrrolo[2,1-b]thiazole or 2,3-dihydropyrrolo[2,1-b]oxazole ring system, R=H, Y=NH2, n=0 or 1 or Het=5-thiazolyl or 3-pyridyl, or A is a heterocyclic ring such that it forms, with pyrrole, a 1H,3H-pyrrolo[1,2-c]thiazole, 2,3-dihydro-1H-pyrrolizine, 5,6,7,8-tetrahydroindolizine, 1,2-dihydro-4H-pyrrolo[1,2-c]-1,3-thiazine, 1H,3H-pyrrolo[1,2-c]oxazole or 1,2-dihydro-4H-pyrrolo[1,2-c]-1,3-oxazine ring system, R=H, Y=NH2 and either Het=5-thiazolyl and n=0 or 1 or Het=3-pyridyl and n=1, the alkyl containing 1 to 4 C as a straight or branched chain, and their acid addition salts, pharmaceutical compositions containing the said pyrrole derivatives and process for their preparation. These pyrrole derivatives are useful in prophylactic and therapeutic treatment of thrombotic complaints.
Inventors:
JIYAN RUI FUAABURU
DANIERU FUARUJIYU
KUROODO JIYAME
DANIERU RABU
DANIERU FUARUJIYU
KUROODO JIYAME
DANIERU RABU
Application Number:
JP26758184A
Publication Date:
September 06, 1985
Filing Date:
December 20, 1984
Export Citation:
Assignee:
RHONE POULENC SANTE
International Classes:
A61K31/435; A61K31/505; A61P7/02; C07D401/06; C07D401/14; C07D417/06; C07D471/04; C07D487/04; C07D498/04; C07D513/04; (IPC1-7): A61K31/435; A61K31/505; C07D471/04; C07D487/04; C07D498/04; C07D513/04
Attorney, Agent or Firm:
Heiyoshi Odashima