Title:
オステオプロテゲリン
Document Type and Number:
Japanese Patent JP4657388
Kind Code:
B2
Abstract:
The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
Inventors:
Boyle, William J.A.
Lacy, David El
Calzone, Frank Theei
Jiang, Min-shi
Lacy, David El
Calzone, Frank Theei
Jiang, Min-shi
Application Number:
JP52386197A
Publication Date:
March 23, 2011
Filing Date:
December 20, 1996
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
A01K67/027; A61K35/74; C12N15/09; A61K38/00; A61K48/00; A61P19/10; A61P43/00; C07K14/705; C07K14/715; C07K16/28; C07K19/00; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12P21/08; C12Q1/68; G01N33/15; G01N33/53; C12R1/19; C12R1/91
Foreign References:
| WO1996028546A1 | ||||
| WO1996026217A1 | ||||
| WO1996005309A1 |
Other References:
Irene Garcia, et al., Transgenic mice expressing high levels of soluble TNF-R1 fusion protein are protected from lethal septic shock and cerebral malaria, and are highly sensitive to Listeria monocytogenes and Leishmania major infections, European Journal of Immunology, 1995年, Vol.25, pages 2401-2407
Attorney, Agent or Firm:
Yoshio Kawaguchi