Title:
オキサジアゾール一過性受容器電位チャネル阻害剤
Document Type and Number:
Japanese Patent JP7095106
Kind Code:
B2
Abstract:
The invention relates to methods of using compounds formula I:and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
Inventors:
Chen, Huifen
Beaumiers, Francis
Terret, Jack Alexander
La Roche-Gautier, Robin
Constantino-Folger, Lee
Lepicier, Ruth
Durie, martin
Gran-meter, Chantal
Stano, Claudio
Volgraph, Matthew
Wilmühle, Elysia
Beaumiers, Francis
Terret, Jack Alexander
La Roche-Gautier, Robin
Constantino-Folger, Lee
Lepicier, Ruth
Durie, martin
Gran-meter, Chantal
Stano, Claudio
Volgraph, Matthew
Wilmühle, Elysia
Application Number:
JP2020550612A
Publication Date:
July 04, 2022
Filing Date:
March 18, 2019
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D471/04; A61K31/437; A61K31/4985; A61K31/5025; A61K31/519; A61K31/52; A61K31/522; A61K31/53; A61K31/5377; A61P1/00; A61P1/04; A61P9/10; A61P11/00; A61P11/06; A61P13/00; A61P13/02; A61P17/04; A61P19/02; A61P27/16; A61P29/00; A61P43/00; C07D473/08; C07D473/18; C07D473/30; C07D473/38; C07D473/40; C07D487/04; C07D498/04; C07D513/04
Domestic Patent References:
| JP2020510031A |
Foreign References:
| WO2017060488A1 |
Other References:
STN International,file REGISTRY [online],[令和3年11月1日検索],CAS Registry No. 1309344-12-4(Entered STN: 14 Jun 2011)
STN International,file REGISTRY [online],[令和3年11月1日検索],CAS Registry No. 1957373-00-0 (Entered STN: 22 Jul 2016), 1309341-59-0 (Entered STN: 14 Jun 2011), 1309229-78-4 (Entered STN: 13 Jun 2011), 1309120-22-6 (Entered STN: 13 Jun 2011), 1070356-02-3 (Entered STN: 03 Nov 2008), 1069804-72-3 (Entered STN: 02 Nov 2008), 1065627-83-9 (Entered STN: 24 Oct 2008)
Laurie B. SCHENKE et al.,Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity,J. Med. Chem.,2016年,vol.59, no.6,p.2794-2809
STN International,file REGISTRY [online],[令和3年11月1日検索],CAS Registry No. 1957373-00-0 (Entered STN: 22 Jul 2016), 1309341-59-0 (Entered STN: 14 Jun 2011), 1309229-78-4 (Entered STN: 13 Jun 2011), 1309120-22-6 (Entered STN: 13 Jun 2011), 1070356-02-3 (Entered STN: 03 Nov 2008), 1069804-72-3 (Entered STN: 02 Nov 2008), 1065627-83-9 (Entered STN: 24 Oct 2008)
Laurie B. SCHENKE et al.,Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity,J. Med. Chem.,2016年,vol.59, no.6,p.2794-2809
Attorney, Agent or Firm:
Patent Attorney Corporation Tsukuni
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