Title:
緑内障の治療においてEP4受容体作動薬として使用するためのオキサゾリジン-2-オンおよびチアゾリジン-2-オン誘導体
Document Type and Number:
Japanese Patent JP2006504679
Kind Code:
A
Abstract:
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.
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Inventors:
Han, Young Shin
Cortchi, Jiyoung
Billow, xavier
Wilson, Mali-Clair
Robert, Yang
Cortchi, Jiyoung
Billow, xavier
Wilson, Mali-Clair
Robert, Yang
Application Number:
JP2004531332A
Publication Date:
February 09, 2006
Filing Date:
August 25, 2003
Export Citation:
Assignee:
Merck Frost Canada and Company
International Classes:
C07D263/24; A61K9/08; A61K31/421; A61K31/426; A61K45/00; A61K47/36; A61P27/02; A61P27/06; A61P43/00; C07D263/20; C07D277/14; C07D413/06; C07D413/10; C07D413/14; C07D417/06; C07D417/10
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura