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Patent Searching and Data


Title:
OXAZOLOISOQUINOLINE COMPOUND
Document Type and Number:
Japanese Patent JPH03130292
Kind Code:
A
Abstract:

NEW MATERIAL:A compound of formula [R1-R3 are H, halogen, hydroxyl group, acyloxy, etc.; or one of R1-R3 is combined with the other to form an O(CH2)mO chain; (n) and (m) are 1-3].

EXAMPLE: (±)-(5R",10S",10aS")-10-Amino-1,3,4,5,10,10a-hexahydro-5-(3,4,5- trimethylphenyl)-7,8-methyldioxyoxazolo[4,3-b]isoquinoline-3-one.

USE: A low toxic antitumor agent.

PREPARATION: An aromatic aldehyde of formula II is subjected to a glycine condensation process, etc., to prepare an oxazoloisoquinoline compound of formula III, which is catalytically reduced in the presence of a catalyst such as palladium carbon in a solvent such as dioxane.


Inventors:
NAKA YOICHI
ICHIYANAGI YUKIMASA
ITO YUKIYASU
YAMAGAMI KEIJI
FUJII AKIHIRO
Application Number:
JP16327290A
Publication Date:
June 04, 1991
Filing Date:
June 20, 1990
Export Citation:
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Assignee:
YOSHITOMI PHARMACEUTICAL
JAPAN TOBACCO INC
International Classes:
C07D498/14; A61K31/42; A61P35/00; (IPC1-7): A61K31/42; C07D498/14
Attorney, Agent or Firm:
Takamiya Castle Masaru