Title:
医学装置の表面上に糖蛋白質を付着させるための酸化法
Document Type and Number:
Japanese Patent JP4177906
Kind Code:
B2
Abstract:
A method for making a medical device having a glycoprotein immobilized on a substrate surface is provided. The method comprises the steps of: (a) oxidizing 1,2-dihydroxy moieties with a periodate to form an aldehyde-functional material; (b) combining the aldehyde-functional material with an amino-functional material to bond the two materials together through an imine moiety; and (c) reacting the imine moiety with a reducing agent to form a secondary amine.
Inventors:
James Earl Keow
Application Number:
JP21649297A
Publication Date:
November 05, 2008
Filing Date:
August 11, 1997
Export Citation:
Assignee:
Medtronic Incorporated
International Classes:
A61L33/00; A61L27/28; A61L27/34; A61L29/08; A61L31/08; A61L31/10; C07K14/00; C08J7/00
Domestic Patent References:
| JP61236814A |
Foreign References:
| US5258501 |
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Hiroyuki Tomita
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Hiroyuki Tomita