Title:
細胞分化誘発物質、細胞増殖抑制剤及び抗腫瘍剤として有用な、酸化されたカロチノイド、レチノイド及び関連する接合されたポリエン及び誘導された分画及び化合物
Document Type and Number:
Japanese Patent JP3983800
Kind Code:
B2
Abstract:
beta -Carotene and canthaxanthin, as representative carotenoids, and to a lesser extent, retinoic acid, a representative retinoid, undergo extensive oxidation to yield substances, insofar as oxidized beta -carotene is a model, which have properties useful as non-toxic agents active against cell proliferation, tumors, and tumorigenic viruses, and useful as promoters of cell differentiation. It is evident from chemical analysis of the highly oxidized beta -carotene product mixture that none of the various forms of vitamin A are present or are present only in minor amounts. Furthermore, the biological activities of oxidized canthaxanthin and retinoic acid, which cannot form, vitamin A, indicate the presence of active substances that are different from vitamin A. Although the anti-proliferative and differentiation promotion activities of oxidized beta -carotene resemble those of vitamin A itself, generally the effects are more powerful for oxidized beta -carotene in a wide variety of circumstances. Unlike vitamin A, the oxidized beta -carotene of the invention is non-toxic.
More Like This:
Inventors:
Burton, Graham
Dalozzewski, Janus
Phipps, Jenny
Praya, Arya
Dalozzewski, Janus
Phipps, Jenny
Praya, Arya
Application Number:
JP50688496A
Publication Date:
September 26, 2007
Filing Date:
August 10, 1995
Export Citation:
Assignee:
NATIONAL RESEARCH COUNCIL OF CANADA
International Classes:
A61K31/745; A61K31/035; C07C403/00; A61K31/07; A61K31/12; A61K31/20; A61P3/02; A61P35/00; A61P43/00; C07C403/14; C07C403/16; C07C403/24; C07G13/00; C07K5/078
Domestic Patent References:
| JP3255198A | ||||
| JP3184966A | ||||
| JP56145269A | ||||
| JP56161370A | ||||
| JP52042850A | ||||
| JP5155873A | ||||
| JP5502243A | ||||
| JP9507226A |
Other References:
Tetrahedron, 1989年, 45(24), p.7679-7694
Tetrahedron, 1993年, 49(4), p.911-928
Tetrahedron Letters, 1991年, 32(33), p.4203-4206
J. Agric. Food Chem., 1990年, 38(5), p.1238-1242
Tetrahedron, 1993年, 49(4), p.911-928
Tetrahedron Letters, 1991年, 32(33), p.4203-4206
J. Agric. Food Chem., 1990年, 38(5), p.1238-1242
Attorney, Agent or Firm:
Takashi Ishida
Yoshio Yoshio
Masaya Nishiyama
Yoshio Yoshio
Masaya Nishiyama