Title:
5HT4受容体アゴニストとしてのオキシインドール誘導体
Document Type and Number:
Japanese Patent JP4130220
Kind Code:
B1
Abstract:
This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, R1, R2, R3, R4 and R5 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 agonistic activity such as, but not limited to, as gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageal disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes or apnea syndrome.
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Inventors:
Kiyoshi Kawamura
Daiki Sone
Riki Uchida
Daiki Sone
Riki Uchida
Application Number:
JP2007556683A
Publication Date:
August 06, 2008
Filing Date:
February 10, 2006
Export Citation:
Assignee:
Pfizer Japan Inc
International Classes:
C07D401/12; A61K31/454; A61P1/00; A61P1/04; A61P1/08; A61P1/10; A61P1/12; A61P1/14; A61P3/10; A61P9/00; A61P9/04; A61P9/06; A61P11/00; A61P25/00; A61P25/04; A61P25/06; A61P25/28; A61P43/00; C07D401/14; C07D405/14
Domestic Patent References:
| JP7504428A | ||||
| JP2001518504A |
Foreign References:
| US5399562 |
Other References:
ROY,M. et al,,Circulation,1996年,Vol.94, No.4,p.817-23
Attorney, Agent or Firm:
Yoshinobu Murofushi