Title:
(オキソ-ピラゾロ[1,5a]ピリミジン-2-イル)アルキル-カルボキサミド
Document Type and Number:
Japanese Patent JP2004525937
Kind Code:
A
Abstract:
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof where the variables R1, R2, A, R4, R5, R6, R6', n, and W are defined herein. These compounds bind to the benzodiazepine site of GABAA receptors are provided and, therefore can be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals.
Inventors:
Li, Guy Inn
Peterson, John, M
Arbo, Pamela
Peterson, John, M
Arbo, Pamela
Application Number:
JP2002576245A
Publication Date:
August 26, 2004
Filing Date:
March 27, 2002
Export Citation:
Assignee:
Neurogen Corporation
International Classes:
G01N33/53; A61K31/519; A61K45/00; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D487/04; G01N33/534; (IPC1-7): C07D487/04; A61K31/519; A61K45/00; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P43/00; G01N33/53; G01N33/534
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda