Title:
Xa因子阻害剤としてのオキシベンズアミド誘導体
Document Type and Number:
Japanese Patent JP4238029
Kind Code:
B2
Abstract:
The present invention relates to compounds of the formula I, R<0>-Q-X-Q'-W-U-V-G-M in which Q; X; Q', U, V, G and M have the meanings indicated in the claims; R<0> is aryl or heteroaryl; and W is selected from aryl, heteroaryl, carbocyclic and heterocyclic groups. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa(FXa) and/or factor VIIa(FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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Inventors:
Marc Nazareth
Derfitt William Ville
Anu Sylvain Paiman
Hans Matter
Gerhard zohler
Uwe Gerlach
Derfitt William Ville
Anu Sylvain Paiman
Hans Matter
Gerhard zohler
Uwe Gerlach
Application Number:
JP2002552926A
Publication Date:
March 11, 2009
Filing Date:
December 15, 2001
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07C235/50; A61K31/166; C07D243/08; A61K31/167; A61K31/18; A61K31/277; A61K31/38; A61K31/4184; A61K31/422; A61K31/435; A61K31/4355; A61K31/437; A61K31/44; A61K31/4418; A61K31/4439; A61K31/445; A61K31/4453; A61K31/4465; A61K31/4468; A61K31/451; A61K31/4525; A61K31/453; A61K31/4535; A61K31/454; A61K31/4545; A61K31/4709; A61K31/495; A61K31/496; A61K31/4965; A61K31/497; A61K31/505; A61K31/506; A61K31/551; A61K31/635; A61P7/00; A61P7/02; A61P7/04; A61P9/00; A61P9/08; A61P9/10; A61P11/00; A61P29/00; A61P43/00; C07C237/42; C07C255/60; C07C311/46; C07C311/51; C07D211/26; C07D211/58; C07D211/96; C07D213/30; C07D213/38; C07D213/40; C07D213/64; C07D213/74; C07D213/89; C07D235/06; C07D235/08; C07D239/42; C07D239/69; C07D241/12; C07D295/12; C07D295/13; C07D295/18; C07D295/192; C07D317/58; C07D333/16; C07D333/58; C07D401/00; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D405/04; C07D405/08; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D413/04; C07D413/14; C07D417/14; C07D471/04; C07D491/04; C07D491/048
Domestic Patent References:
| JP11171856A | ||||
| JP6511238A | ||||
| JP59029677A | ||||
| JP57149254A | ||||
| JP2004515492A | ||||
| JP7304715A |
Foreign References:
| WO2000066120A1 | ||||
| WO1999000356A1 |
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Hiroshi Sugimoto
Kosuke Nishimura
Hiroshi Sugimoto