Title:
OXYGEN ISOTOPE-LABELED COMPOUND, METHOD FOR PRODUCING OXYGEN ISOTOPE-LABELED COMPOUND, OXYGEN ISOTOPE-LABELED UREA DERIVATIVE COMPOUND, AND METHOD FOR PRODUCING OXYGEN ISOTOPE-LABELED UREA DERIVATIVE COMPOUND
Document Type and Number:
Japanese Patent JP2019178128
Kind Code:
A
Abstract:
To provide a novel oxygen isotope-labeled compound in which a carbonyl site is substituted with heavy oxygen, and a method for producing the same.SOLUTION: The present invention provides a method for producing an oxygen isotope-labeled compound represented by formula (1), including reacting dichloromethylenedimethylammonium chloride and a compound represented by R-OH, and oxygen isotope-labeled water (HY). (Ris an aryl group substituted with a C1-C4 alkyl group, a C1-C4 alkoxy group, a nitro group, a C1-C4 fluoroalkyl group or the like, or an unsubstituted aryl group; a heteroaryl group substituted with a C1-C4 alkyl group, a C1-C4 alkoxy group, a nitro group, a C1-C4 fluoroalkyl group or the like, or an unsubstituted heteroaryl group; Y isO orO).SELECTED DRAWING: None
Inventors:
TOKUOKA SHINYA
SHIMOHIRA HARUKI
SHIMOHIRA HARUKI
Application Number:
JP2018070237A
Publication Date:
October 17, 2019
Filing Date:
March 30, 2018
Export Citation:
Assignee:
TAIYO NIPPON SANSO CORP
International Classes:
C07C69/96; C07B59/00; C07C68/00; C07C68/02; C07C273/18; C07C275/30; C07D317/46
Domestic Patent References:
| JP2016023162A | 2016-02-08 |
Other References:
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LARRY W. HILSCHER ET AL., BIOCHEMISTRY, vol. 24, no. 21, JPN6021044764, 1985, pages 5888 - 5893, ISSN: 0004639463
MICHEAL P. GROZIAK ET AL., JOURNAL OF ORGANIC CHEMISTRY, vol. 51, no. 7, JPN6021044767, 1986, pages 1065 - 1069, ISSN: 0004639464
B. ROUSSEAU ET AL., JOURNAL OF PHYSICAL CHEMISTRY A, vol. 102, no. 32, JPN6021044766, 1998, pages 6540 - 6548, ISSN: 0004639465
ANTONIO AMANTEA ET AL., HELVETICA CHIMICA ACTA, vol. 79, no. 1, JPN6021044765, 1996, pages 244 - 254, ISSN: 0004639466
Attorney, Agent or Firm:
Shiga International Patent Office