Title:
ＰＣＲ産物の検出方法
Document Type and Number:
Japanese Patent JP6962596
Kind Code:
B2
Abstract:
A method for detecting a nucleic acid molecule in a biological sample includes amplifying a nucleic acid molecule to generate an amplicon having a single 5′-tail and coupling the 5′-tail to one of a plurality of capture probes on a surface of a sensor. The amplicon is converted to a single strand molecule and a target-specific catalyst cluster is bound to the single strand molecule. The catalyst cluster is subjected to metallization in order to detect the target nucleic acid.
Inventors:
Richard S. Murante
Bella Tanaus
Bella Tanaus
Application Number:
JP2019512950A
Publication Date:
November 05, 2021
Filing Date:
May 18, 2017
Export Citation:
Assignee:
Integrated Nano-Technologies, Inc.
International Classes:
C12Q1/6825; C12M1/34; C12Q1/34; C12Q1/6834; C12Q1/686
Domestic Patent References:
| JP2005525084A | ||||
| JP2006501486A | ||||
| JP2002522748A | ||||
| JP2005520130A | ||||
| JP2002540803A |
Other References:
Analyst 128 917-923 (2003)
Nucleic Acids Research 17 5865 (1989)
Nucleic Acids Research 17 5865 (1989)
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidena Tsuda
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidena Tsuda