Title:
安定性が向上したＰＤＧＦ及びＶＥＧＦアプタマー並びにＰＤＧＦ及びＶＥＧＦ媒介性の疾患及び障害の治療におけるそれらの使用
Document Type and Number:
Japanese Patent JP6949916
Kind Code:
B2
Abstract:
Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
Inventors:
Janic, Neboisa
Doloré, Daniel W
Julinas, Amy Dee
Tsang, Ji
Beaukrian, Michael
Doloré, Daniel W
Julinas, Amy Dee
Tsang, Ji
Beaukrian, Michael
Application Number:
JP2019176480A
Publication Date:
October 13, 2021
Filing Date:
September 27, 2019
Export Citation:
Assignee:
SomaLogic, Inc.
International Classes:
C12N15/115; A61K31/7115; A61K31/7125; A61K48/00; A61P9/10; A61P11/00; A61P13/12; A61P27/02; A61P27/06; A61P27/12; A61P35/00; A61P35/02
Domestic Patent References:
| JP2007525177A | ||||
| JP2013523177A | ||||
| JP2004533861A |
Foreign References:
| WO2005052121A2 | ||||
| WO2006050498A2 |
Other References:
Proc. Natl. Acad. Sci. USA,2012年,Vol. 109, No. 49,p. 19971-19976
Attorney, Agent or Firm:
Osamu Yamamoto
Shinjiro Ono
Toru Miyamae
Motoharu Nakanishi
Akiko Nakahama
Shinjiro Ono
Toru Miyamae
Motoharu Nakanishi
Akiko Nakahama