Title:
PGC-1β、新規PGC-1相同体およびその用途
Document Type and Number:
Japanese Patent JP2005514921
Kind Code:
A
Abstract:
The invention provides isolated nucleic acid molecules, designated PGC-1beta nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1beta nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1beta gene has been introduced or disrupted. The invention still further provides isolated PGC-1beta proteins, fusion proteins, antigenic peptides and anti-PGC-1beta antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
Inventors:
Spiegelmann, Bruce, M.
Lynn, Jeantier
Lynn, Jeantier
Application Number:
JP2003544182A
Publication Date:
May 26, 2005
Filing Date:
November 08, 2002
Export Citation:
Assignee:
Dana-Farber Cancer Institute, Inc.
International Classes:
G01N33/50; A61K45/00; A61K48/00; A61P3/10; A61P9/00; A61P25/00; A61P25/16; A61P43/00; C07H21/04; C07K14/47; C07K16/18; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/06; C12N5/10; C12N9/20; C12N15/09; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; G01N33/567; (IPC1-7): C12N15/09; A61K45/00; A61K48/00; A61P3/10; A61P9/00; A61P25/00; A61P25/16; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Junji Endo
Tomimasa Konishi
Tomoko Nakamura
Tomimasa Konishi
Tomoko Nakamura