Title:
治療薬を送達させるためのｐＨ感受性リンカー
Document Type and Number:
Japanese Patent JP6875371
Kind Code:
B2
Abstract:
The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.
Inventors:
Liao, Yui-Chun
Hoang, Wei-Chan
Chen, Chia-Nang
Lynn, Hoang-Yui
Rin, Chin-e
Tsai, Mon-Chui
Sue, One-E
Chi, Lee-Lin
Chao, Yeah-Sue
Woo, E-Hong
Hoang, Wei-Chan
Chen, Chia-Nang
Lynn, Hoang-Yui
Rin, Chin-e
Tsai, Mon-Chui
Sue, One-E
Chi, Lee-Lin
Chao, Yeah-Sue
Woo, E-Hong
Application Number:
JP2018502821A
Publication Date:
May 26, 2021
Filing Date:
July 21, 2016
Export Citation:
Assignee:
GNT Biotech and Medicals Corporation
International Classes:
C07C243/28; A61K31/4745; A61K31/704; A61K33/24; A61K33/242; A61K33/243; A61K39/395; A61K45/00; A61K47/02; A61K47/34; A61K47/52; C07C243/34; C07D339/04
Domestic Patent References:
| JP2013523877A |
Foreign References:
| US20110286107 |
Other References:
Biomaterials,2014年,Vol.35, No.10,pp.3480-3487
ACS NANO,2011年,Vol.5,No.5,p.3679-3692
Biomaterials,2014年,Vol.35, No.2,pp.836-845
Bioconjugate Chemistry,2003年,Vol.14, No.6,pp.1122-1132
ACS NANO,2011年,Vol.5,No.5,p.3679-3692
Biomaterials,2014年,Vol.35, No.2,pp.836-845
Bioconjugate Chemistry,2003年,Vol.14, No.6,pp.1122-1132
Attorney, Agent or Firm:
Patent Business Corporation Unias International Patent Office