Title:
ＰＩＶＫＡ−ＩＩの測定方法、及びＰＩＶＫＡ−ＩＩ免疫測定試薬又はキットの製造方法
Document Type and Number:
Japanese Patent JP6713478
Kind Code:
B2
Abstract:
Disclosed is a means of enabling the construction of a more accurate PIVKA-II immunoassay system using monoclonal antibodies against human prothrombin. The PIVKA-II assay method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using an anti-PIVKA-II antibody or an antigen-binding fragment thereof which specifically binds to PIVKA-II and a mixture of a first anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophilic PIVKA-II molecules and a second anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophobic PIVKA-II molecules.
Inventors:
Yoshiyuki Kitamura
Katsumi Aoyagi
Katsumi Aoyagi
Application Number:
JP2017544222A
Publication Date:
June 24, 2020
Filing Date:
October 06, 2016
Export Citation:
Assignee:
FUJIREBIO INC.
Sekisui Medical Co., Ltd.
Sekisui Medical Co., Ltd.
International Classes:
G01N33/53; G01N33/577
Domestic Patent References:
| JP2014035278A | ||||
| JP9043237A | ||||
| JP60060557A | ||||
| JP2013541936A | ||||
| JP10197532A | ||||
| JP2000146981A |
Foreign References:
| US20050031663 |
Attorney, Agent or Firm:
Patent Service Corporation Tanigawa International Patent Office