POLYMER-siRNA NANOPARTICLE CARRIER SIMULTANEOUSLY CONNECTED BY CHARGE COUPLING AND BIODEGRADABLE COVALENT BONDING, AND METHOD FOR PRODUCING THE SAME

Japanese Patent JP2012055300

A

To provide a polymer-siRNA carrier and a method for producing the polymer-siRNA carrier high in siRNA delivery efficiency to a target site in a living body, permitting efficient delivery of a therapeutic siRNA to the target site such as cancer tissue in the living body even with administration of comparatively low concentration and usable in a wide range for the treatment of various diseases.

The polymer-siRNA carrier has a structure A-B in which a polymer (A) and a siRNA (B) are connected simultaneously by charge coupling and biodegradable covalent bonding, wherein (A) is a polymer having positive charge and a functional group, and (B) is a siRNA having a functional group at one end or both ends thereof.

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KIM KWANG MEYUNG
KWON ICK CHAN
CHOI KUIWON
HUH MYUNGN SOOK
LEE SEUNG YOUNG
LEE SO JIN

JP2010232764A

March 22, 2012

October 15, 2010

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KOREA INST SCI & TECH

C12N15/113; A61K31/713; A61K47/48; A61P1/16; A61P3/04; A61P3/10; A61P25/16; A61P29/00; A61P31/18; A61P35/00

JPN6013010251; Ｊ．　Ｃｏｎｔｒｏｌ．　Ｒｅｌｅａｓｅ． Ｖｏｌ．　１４１, 201002, ｐ．　３３９-３４６
JPN6013010252; Ｊ．　Ｃｏｎｔｒｏｌ．　Ｒｅｌｅａｓｅ． Ｖｏｌ．　１４４, 201005, ｐ．　４６-５４
JPN6013010253; Ｐｈａｒｍ．　Ｒｅｓ． Ｖｏｌ．　２４，　Ｎｏ．　１, 2006, ｐ．　１５７-１６７
JPN6013010254; Ｂｉｏｃｈｅｍ．　Ｂｉｏｐｈｙｓ．　Ｒｅｓ．　Ｃｏｍｍｕｎ． Ｖｏｌ．　３５７, 2007, ｐ．　５１１-５１６
JPN6013010255; Ｍｏｌ．　Ｐｈａｒｍ． Ｖｏｌ．　６，　Ｎｏ．　３, 2009, ｐ．　７５２-７６２
JPN6013010256; Ｉｎｔ．　Ｊ．　Ｐｈａｒｍ． Ｖｏｌ．　３９７, 20100707, ｐ．　９２-９５

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Tatsunori Ikeda

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