Title:
【発明の名称】コアセルベーションによるイオン架橋ポリホスファゼンマイクロスフェアの調製
Document Type and Number:
Japanese Patent JP2000516129
Kind Code:
A
Abstract:
A method is provided for preparing polyphosphazene microspheres wherein the polyphosphazene microspheres are produced by coacervation. A solution containing a polyphosphazene is admixed with a solution containing a salt of a monovalent ion such as a salt of a Group I element (for example, NaCl) to form a dispersion containing polyphosphazene coacervate microdroplets. The dispersion then is admixed with a solution containing a salt of a multivalent ion, such as a salt of a Group II element (for example, CaCl2) to form a suspension of polyphosphazene microspheres. The polyphosphazene microspheres then are recovered from the suspension. Such method enables one to obtain high yields of microspheres having a controlled size distribution. Polyphosphazene microspheres containing biological material can be produced by providing a biological material in the polyphosphazene solution that is mixed with the solution containing a salt of a monovalent ion. The biological material may be an antigen or other biological material selected from proteins, nucleic acids, polysaccharides and synthetic compounds having biological activity.
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Inventors:
Andrianov, Alexander, Kay.
Chen, Jiangping
Chen, Jiangping
Application Number:
JP50415398A
Publication Date:
December 05, 2000
Filing Date:
June 10, 1997
Export Citation:
Assignee:
Viras Research Institute
International Classes:
C12N11/08; A61K9/16; A61K9/50; A61K31/7088; A61K31/711; A61K31/715; A61K38/00; A61K39/00; A61K39/05; A61K39/08; A61K39/095; A61K39/102; A61K39/13; A61K39/145; A61K39/15; A61K39/165; A61K39/20; A61K39/21; A61K39/245; A61K39/29; A61K47/34; A61P31/04; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; B01J13/08; C07F9/06; C07K17/08; C08G79/02; C08L85/02; A61K9/00; A61K48/00; (IPC1-7): B01J13/08; A61K9/50; A61K31/7088; A61K31/711; A61K31/715; A61K38/00; A61K39/00; A61K39/05; A61K39/08; A61K39/095; A61K39/102; A61K39/13; A61K39/15; A61K39/165; A61K39/20; A61K39/21; A61K39/245; A61K39/29; A61K47/34; A61P31/04; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; C07K17/08; C08L85/02; C12N11/08
Attorney, Agent or Firm:
Hiroyuki Niwa