Title:
【発明の名称】多孔性セルロースマトリクスの製造方法
Document Type and Number:
Japanese Patent JPH05507696
Kind Code:
A
Abstract:
PCT No. PCT/SE91/00396 Sec. 371 Date Nov. 30, 1992 Sec. 102(e) Date Nov. 30, 1992 PCT Filed Jun. 5, 1991 PCT Pub. No. WO91/18590 PCT Pub. Date Dec. 12, 1991A process for the manufacture of porous cellulose particles, which have regular shape, and a capacity of sorbing 1.5-9 times of their own weight of water, a tap bulk density of less than 0.85 g/ml is provided. The process for the manufacture of these porous cellulose matrices is performed by mechanically treating of hydrolyzed cellulose in a wet stage. The cellulose matrices have preferably a size of at least 0.1 mm and a tap bulk density of 0.1-0.7 g/ml. A bioactive substance or bioactive substances could be sorbed, precipitated or sublimized into the porous structure of the matrices. The matrices can be admixed with drugs or drug containing granules in order to improve the tabletting and tablet properties and thereafter compressed. Drug loaded matrices can be used for direct compression of tablets.
Inventors:
Exvo Ragnar
Ericsson Kale Gunner
Nikvist Per Gustav Hakan
Ragnarsson Gate Andres
Ericsson Kale Gunner
Nikvist Per Gustav Hakan
Ragnarsson Gate Andres
Application Number:
JP51058791A
Publication Date:
November 04, 1993
Filing Date:
June 05, 1991
Export Citation:
Assignee:
Mold Pharmacia Actibolague
International Classes:
A61K9/16; A61K9/20; A61K9/22; A61K9/52; A61K47/38; C08B15/02; C08J9/26; C08L1/02; (IPC1-7): A61K47/38; A61K9/20
Attorney, Agent or Firm:
Hideo Dobashi (1 outside)