Title:
【発明の名称】γ-ブチロラクタム類の製造方法
Document Type and Number:
Japanese Patent JPH0794431
Kind Code:
B2
Abstract:
A process for the preparation of a C(3)-C(4)-transconfigurated gamma -butyrolactam of the formula (I) (I) in which R1 represents hydrogen or alkyl, aryl or aralkyl with in each case up to 10 carbon atoms and R2 and R3 are identical or different and represent hydrogen, alkyl, aryl, aralkyl, alkoxy, aryloxy or aralkoxy with in each case up to 10 carbon atoms, acyl with up to 18 carbon atoms, trifluoromethyl, trifluoromethoxy, nitro, hydroxyl, halogen, amino, carboxyl, sulpho, dialkylamino with up to 4 carbon atoms in the alkyl groups or acylamino with up to 18 carbon atoms, in the form of their isomers, isomer mixtures, racemates or optical antipodes, comprising oxidizing a compound of the formula (II) (II) in which R1, R2 and R3 have the above-mentioned meanings, in an inert organic solvent in the presence of a base. Such gamma -butyrolactams have an antiamnesic action.
Inventors:
Wolfgang Hartwitzhi
Application Number:
JP24560786A
Publication Date:
October 11, 1995
Filing Date:
October 17, 1986
Export Citation:
Assignee:
Bayer Actien Gezershyaft
Chinese Academy of Medical Sciences
Chinese Academy of Medical Sciences
International Classes:
A61K31/40; A61K31/4015; A61P25/28; C07B53/00; C07D201/02; C07D207/12; C07D207/16; C07D207/26; C07D207/267; C07D207/273; C07D207/28; C07D; (IPC1-7): C07D207/273
Domestic Patent References:
| JP62187450A |
Other References:
Ａｎｎ．Ｃｈｉｍ．（Ｒｏｍｅ），５８（６），６３７−５０（１９６８）
Ｆａｒｍａｃｏ．ＥｄｉｚｉｏｎｅＳｃｉｅｎｔｉｆｉｃａ，２７（７），５４８−５８（１９７２）
Ｆａｒｍａｃｏ．ＥｄｉｚｉｏｎｅＳｃｉｅｎｔｉｆｉｃａ，２７（７），５４８−５８（１９７２）
Attorney, Agent or Firm:
Heiyoshi Odashima
Next Patent: JPH0794432