Title:
骨疾患のPTHRPに基づく予測と診断
Document Type and Number:
Japanese Patent JP2005528117
Kind Code:
A
Abstract:
The invention provides method of diagnosing bone disease and/or a susceptibility thereto, in an individual. The method includes screening a biological sample obtained from the individual for one or more genetic indicators of bone disease in said PTHrP gene of the individual, and diagnosing the individual based on a characterization of the genetic indictor(s) detected. A genetic indicator of the invention preferably includes a genetic segment of a PTHrP gene. More preferably, a genetic segment of a PTHrP gene includes a VNTR containing region. The invention further relates to a transgenic non-human mammal for the study of bone disease and/or bone conditions, the mammal having a disruption or inactivation of a PTHrP gene or portion thereof specifically in osteoblast cells.
Inventors:
Andrew Calapris
David Goltzmann
David Goltzmann
Application Number:
JP2004510466A
Publication Date:
September 22, 2005
Filing Date:
May 30, 2003
Export Citation:
Assignee:
McGill University
International Classes:
A01K67/027; A61K48/00; A61P19/08; A61P19/10; C12N15/09; C12Q1/68; G01N33/15; G01N33/50; (IPC1-7): C12N15/09; A01K67/027; A61K48/00; A61P19/08; A61P19/10; C12Q1/68; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa