Title:
PAIN STUDY, IMAGING AND THERAPEUTIC METHOD, AND COMPOSITION FOR PAIN STUDY, IMAGING AND THERAPY
Document Type and Number:
Japanese Patent JP2015057424
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a pain study, imaging and therapeutic method, and a composition for pain study, imaging and therapy.SOLUTION: A saxitoxin analogue compound, a composition, a pharmaceutical composition, a synthesis method of a saxitoxin analog, an imaging method, and a therapeutic method including a pain therapeutic method are provided. Saxitoxin (STX), gonyautoxin (GTX) and zetekitoxin, and a variant STX compound are bound to a sodium channel and effective for reducing or blocking sodium ion flowing through such a channel. Such a channel block affects nerve and muscle actions and can be effective for reducing and blocking pain sensation, for relaxing the muscle, for reducing muscle spasm, and for reducing wrinkles.
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Inventors:
JUSTIN DUBOIS
JOHN MULCAHY
BRIAN ANDRESEN
YEOMANS DAVID C
SANDIP BISWAL
JOHN MULCAHY
BRIAN ANDRESEN
YEOMANS DAVID C
SANDIP BISWAL
Application Number:
JP2014237457A
Publication Date:
March 26, 2015
Filing Date:
November 25, 2014
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR
International Classes:
C07D487/14; A61K31/519; A61K39/395; A61K47/48; A61K49/00; A61K51/00; A61P1/02; A61P9/06; A61P13/00; A61P13/10; A61P15/00; A61P17/00; A61P19/02; A61P21/00; A61P21/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P27/02; A61P27/16; A61P35/00; A61P43/00; C07D498/22; C07D519/00; C07J43/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita