Title:
PALLADIUM-CATALYZED NUCLEOSIDE MODIFICATION METHOD USING NUCLEOPHILE AND CARBON MONOXIDE
Document Type and Number:
Japanese Patent JP2009057388
Kind Code:
A
Abstract:
To provide a production method of a modified nucleoside or nucleotide using a palladium catalyst, a nucleophile and carbon monoxide.
The production method of the modified nucleoside comprises a step of reacting a nucleoside starting material having a leaving group bound to a carbon atom in the nucleoside starting material with the nucleophile and carbon monoxide in the presence of the palladium catalyst and subsequently isolating the modified nucleoside.
Inventors:
TU CHI
DEWEY TORIN
EATON BRUCE
DEWEY TORIN
EATON BRUCE
Application Number:
JP2008262208A
Publication Date:
March 19, 2009
Filing Date:
October 08, 2008
Export Citation:
Assignee:
GILEAD SCIENCES INC
International Classes:
C07H19/067; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61P31/04; A61P31/10; A61P31/12; A61P35/00; C07H19/06; C07H19/073; C07H19/10; C07H19/16; C07H19/167; C07H19/173; C07H19/20; C07B61/00
Domestic Patent References:
| JPS5536418A | 1980-03-14 | |||
| JPS5862190A | 1983-04-13 | |||
| JPH08511527A | 1996-12-03 | |||
| JPH11506107A | 1999-06-02 |
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JPN4007021347; Ｃｏｌｌｅｃｔｉｏｎ Ｃｚｅｃｈｏｓｌｏｖ． Ｃｈｅｍ． Ｃｏｍｍｕｎ． Ｖｏｌ．３７, 1972, ｐｐ．１５５５-１５７６
JPN6009031416; 第４版 実験化学講座２５ 有機合成ＶＩＩ -有機金属試薬による合成- 第３刷, 19950410, ｐｐ．３９６-４２７
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Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
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