Title:
ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子(VLP)
Document Type and Number:
Japanese Patent JP2011509661
Kind Code:
A
Abstract:
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
Inventors:
Doust, Marc-Andre
Coacher, Manon
Orus, Frederick
Trepaniere, Sonia
La Boyer, Pierre-Olivia
Dargis, Michelle
Vegina, Louis-Philippe
Laundry, Natalie
Coacher, Manon
Orus, Frederick
Trepaniere, Sonia
La Boyer, Pierre-Olivia
Dargis, Michelle
Vegina, Louis-Philippe
Laundry, Natalie
Application Number:
JP2010542486A
Publication Date:
March 31, 2011
Filing Date:
January 12, 2009
Export Citation:
Assignee:
Medicago Inc.
International Classes:
C12N15/09; A01H5/00; A01H6/04; A23L33/00; A61K35/76; A61K36/00; A61K36/81; A61K38/00; A61K39/145; A61K47/24; A61K47/28; A61K47/44; A61K48/00; A61P31/16; A61P37/04; C12N7/00; C12N7/01; C12N15/82; A61K39/00
Foreign References:
| WO2004098533A2 | 2004-11-18 |
Other References:
JPN6013043280; 'Ｔｒｅｎｄｓ ｉｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ' ２００７， Ｖｏｌ．２５， Ｎｏ．７， ｐｐ．３１７-３２３
JPN6013043282; 'Ｍｅｔｈｏｄｓ' ２００６， Ｖｏｌ．４０， ｐｐ．６０-６５
JPN6013043285; 'Ｖａｃｃｉｎｅ' ２００５， Ｖｏｌ．２３， ｐｐ．５７５１-５７５９
JPN6013043279; 'Ｉｎｆｌｕｅｎｚａ ａｎｄ Ｏｔｈｅｒ Ｒｅｓｐｉｒａｔｏｒｙ Ｖｉｒｕｓｅｓ' ２００７， Ｖｏｌ．１， ｐｐ．１９-２５
JPN6013043282; 'Ｍｅｔｈｏｄｓ' ２００６， Ｖｏｌ．４０， ｐｐ．６０-６５
JPN6013043285; 'Ｖａｃｃｉｎｅ' ２００５， Ｖｏｌ．２３， ｐｐ．５７５１-５７５９
JPN6013043279; 'Ｉｎｆｌｕｅｎｚａ ａｎｄ Ｏｔｈｅｒ Ｒｅｓｐｉｒａｔｏｒｙ Ｖｉｒｕｓｅｓ' ２００７， Ｖｏｌ．１， ｐｐ．１９-２５
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita