Title:
マイクロ流体制御による区画化されたスクリーニング
Document Type and Number:
Japanese Patent JP4829240
Kind Code:
B2
Abstract:
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
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Inventors:
Andrew Griffith
David Waits
Darren Link
Ann Kung Ho
Jerome Vivet
David Waits
Darren Link
Ann Kung Ho
Jerome Vivet
Application Number:
JP2007536255A
Publication Date:
December 07, 2011
Filing Date:
October 12, 2005
Export Citation:
Assignee:
Medical Research Council
International Classes:
G01N35/08; B01F5/02; B01F5/06; B01F13/00; B01J19/00; B01L3/00; C07B61/00; C12Q1/00; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/543; G01N33/555; G01N37/00; B01F3/08; C40B50/08; G01N15/14
Domestic Patent References:
| JP2001509380A | 2001-07-24 | |||
| JP2002505590A | 2002-02-19 | |||
| JP2006507921A | 2006-03-09 | |||
| JP2008518884A | 2008-06-05 | |||
| JP2001078786A | 2001-03-27 | |||
| JP2006521922A | 2006-09-28 | |||
| JP2006522325A | 2006-09-28 |
Foreign References:
| WO2002066992A1 | 2002-08-29 | |||
| WO2004002627A2 | 2004-01-08 | |||
| WO2002023163A1 | 2002-03-21 | |||
| WO2004024917A2 | 2004-03-25 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita