Title:
PDGF AND VEGF BINDING APTAMERS AND THEIR USE IN TREATING PDGF AND VEGF MEDIATED CONDITIONS
Document Type and Number:
Japanese Patent JP2019068851
Kind Code:
A
Abstract:
To provide aptamers useful for preventing and treating disorders in which PDGF and/or VEGF has been implicated.SOLUTION: An aptamer comprises a sequence: 5'-NZVSLnS'V'ZACNNmGCGZZZAZAGCG-3' (SEQ ID NO: 500), wherein V is selected from an A, C or G; V' is selected from a C, G or Z, wherein V' is complementary to V; S and S' are independently selected from a C or G, wherein S and S' are complementary to each other; each N is independently selected from any naturally occurring or modified nucleotide; each Z is independently selected from a modified pyrimidine; L is selected from any naturally occurring or modified nucleotide, a hydrocarbon linker, a polyethylene glycol linker or a spacer selected from combinations thereof; n is 0 to 20; and m is 0 to 20; and wherein one or more nucleotide insertions are optionally included, as needed.SELECTED DRAWING: Figure 1-1
Inventors:
THALE C JARVIS
JOHN C ROHLOFF
AMY D GELINAS
CHANG CHI
DANIEL W DROLET
SHEELA M WAUGH
NEBOJSA JANJIC
JOHN C ROHLOFF
AMY D GELINAS
CHANG CHI
DANIEL W DROLET
SHEELA M WAUGH
NEBOJSA JANJIC
Application Number:
JP2019006667A
Publication Date:
May 09, 2019
Filing Date:
January 18, 2019
Export Citation:
Assignee:
SOMALOGIC INC
International Classes:
C12N15/115; A61K31/7088; A61K47/60; A61K48/00; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P27/02; A61P27/06; A61P27/12; A61P35/00; A61P35/02; A61P43/00; C07H21/04
Domestic Patent References:
| JP2007525177A | 2007-09-06 |
Foreign References:
| WO2005052121A2 | 2005-06-09 | |||
| WO2006050498A2 | 2006-05-11 | |||
| WO2011130195A1 | 2011-10-20 |
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Akiko Nakahama
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Akiko Nakahama