Title:
ガチフロキサシンの小児科用製剤
Document Type and Number:
Japanese Patent JP4617475
Kind Code:
B2
Abstract:
There is provided in accordance with the present invention the quinolone antibacterial gatifloxacin adequately taste-masked so that it can be utilized for pediatric formulations. A crystalline co-precipitate of gatifloxacin and one or both of stearic acid and palmitic acid in a narrow weight ratio has been found to effectively mask the bitter taste of gatifloxacin. The taste of gatifloxacin is effectively masked in the mouth and in aqueous suspension through a full dosage cycle, typically fourteen days. Gatifloxacin in the subject crystalline co-precipitates has been found to be readily available for absorption from the stomach.
Inventors:
Krishna Swami S. Lagavan
Sunanda A Lana Dive
Kenneth S. Bemveneck
Rootfi bunkerule
Veronique Tronyon
Richard G. Corao
Luigi Esposito
Sunanda A Lana Dive
Kenneth S. Bemveneck
Rootfi bunkerule
Veronique Tronyon
Richard G. Corao
Luigi Esposito
Application Number:
JP2003506621A
Publication Date:
January 26, 2011
Filing Date:
May 10, 2002
Export Citation:
Assignee:
Kyorin Pharmaceutical Co., Ltd.
International Classes:
A61K31/496; A61K31/445; C07D401/04; A61K47/12; A61P31/04; C07D215/56; C07D401/10
Domestic Patent References:
| JP10203985A |
Foreign References:
| WO1999058129A1 |
Attorney, Agent or Firm:
Mizuno Katsufumi
Masayuki Kishida
Hisamatsu Yosuke
Masayuki Kishida
Hisamatsu Yosuke