PENTANOIC ACID DERIVATIVE, ITS PRODUCTION AND MEDICINE CONTAINING THE SAME

Title:

PENTANOIC ACID DERIVATIVE, ITS PRODUCTION AND MEDICINE CONTAINING THE SAME

Document Type and Number:

Japanese Patent JP2935110

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To obtain the subject new compound capable of improving the GABAA receptor response of reactive astrocyte and thereby useful for preventing and treating neurodegenerative diseases caused by the functional abnormality of the astrocyte.
SOLUTION: A compound of formula I [R1 is a 1-10C alkyl whose one carbon atom may be substituted by one to three fluorine atoms; R2 is hydroxy, NR3R4 (R3, R4 are each H, a 1-4C alkyl, etc.), etc., wherein R1 is not F(CH2)4, F(CH2)5, F(CH2)6, F3C-CH2], e.g. 5-fluoro-2-propylpentanoic acid. The compound of formula I is obtained by several methods including a method comprising catalytically hydrogenating a compound of formula II (R1a is a 1-10C alkyl substituted by one or two fluorine atoms; R2a is a 1-4C alkoxy).

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Inventors:

OONADA SHUICHI
KISHIMOTO KAZUO
TATEISHI SHIGETO
OONO HIROYUKI

Application Number:

JP3225598A

Publication Date:

August 16, 1999

Filing Date:

January 29, 1998

Export Citation:

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Assignee:

ONO YAKUHIN KOGYO KK

International Classes:

A61K31/20; A61K31/00; A61K31/16; A61K31/165; A61K31/19; A61K31/192; A61K31/195; A61K31/197; A61K31/22; A61K31/23; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/445; A61K31/495; A61K31/535; A61K31/5375; A61P25/00; A61P25/04; A61P25/28; A61P43/00; C07B61/00; C07C51/06; C07C51/36; C07C53/126; C07C53/128; C07C53/134; C07C53/19; C07C53/21; C07C53/23; C07C57/03; C07C57/30; C07C59/125; C07C59/135; C07C59/68; C07C67/303; C07C69/02; C07C69/22; C07C69/24; C07C69/34; C07C69/533; C07C69/612; C07C69/63; C07C69/708; C07C231/12; C07C233/05; C07C233/07; C07C233/11; C07C233/12; C07C233/22; C07C233/25; C07C233/43; C07C233/47; C07C233/54; C07C323/52; C07D213/40; C07D213/72; C07D213/75; C07D295/18; C07D295/185; (IPC1-7): C07C53/21; A61K31/00; A61K31/165; A61K31/195; A61K31/20; A61K31/22; A61K31/23; A61K31/44; A61K31/445; A61K31/495; A61K31/535; C07C51/36; C07C69/63; C07C233/05; C07C233/07; C07C233/25; C07C233/54; C07D213/40; C07D213/75; C07D295/18

Attorney, Agent or Firm:

Kunihisa Oya (1 outside)

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