Title:
PEPTIDE OR ANTIBODY THAT INHIBITS ADHESION OF PLATELET
Document Type and Number:
Japanese Patent JP3420747
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method for preparing a monoclonal antibody which contains a specifically bound cell, surface receptor and ligand, is expressed by a receptor-ligand complex, and immunologically reacts with a ligand induction-binding site since antigen-determining groups have been found which are expressed when a cell surface receptor specifically binds to a ligand but are not expressed by a non-occupying receptor or non-binding region ligand.
SOLUTION: A DNA and recombinant DNA molecule containing a DNA sequence encoding a part of a structural gene of GPIIb heavy chain (H chain) (hGPIIb) forming an antigen-determining group when platelet-related GPIIb-IIIa binds to fibrinogen, a polypeptide analogue which is potential antigen- determining group of hGPIIb, and an antibody which immunologically reacts with the polypeptide are provided.
Inventors:
Plow Edward F
Ginsburg Mark H
Ginsburg Mark H
Application Number:
JP2000349824A
Publication Date:
June 30, 2003
Filing Date:
July 08, 1988
Export Citation:
Assignee:
Scripps Clinic and Research Foundation
International Classes:
A61K38/00; A61K39/395; A61K49/00; A61P7/02; C07K14/00; C07K14/47; C07K14/705; C07K14/745; C07K16/00; C07K16/18; C07K16/28; G01N33/50; C07K16/36; C12N5/10; C12N15/02; C12N15/09; C12P21/08; G01N33/15; G01N33/53; G01N33/566; G01N33/569; G01N33/577; C12R1/91; (IPC1-7): C12N15/09; C07K14/745; C07K16/36; C12N5/10; C12N15/02; G01N33/15; G01N33/50; G01N33/53; G01N33/577
Other References:
Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，１９８７年 ６月２５日，Ｖｏｌ．２６２，Ｎｏ．１８，ｐｐ．８４７６−８４８２
Ｊ．Ｃｅｌｌ．Ｂｉｏｌ．，Ｖｏｌ．９９，ｐｐ．２０５６−２０６０
Ｊ．Ｃｌｉｎ．Ｉｎｖｅｓｔ．，Ｖｏｌ．７８，ｐｐ．１１０３−１１１１
Ｊ．Ｃｅｌｌ．Ｂｉｏｌ．，Ｖｏｌ．９９，ｐｐ．２０５６−２０６０
Ｊ．Ｃｌｉｎ．Ｉｎｖｅｓｔ．，Ｖｏｌ．７８，ｐｐ．１１０３−１１１１
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)