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Title:
PEPTIDE-BASED PASSIVE IMMUNIZATION THERAPY FOR TREATMENT OF ATHEROSCLEROSIS
Document Type and Number:
Japanese Patent JP2010136721
Kind Code:
A
Abstract:

To provide an antibody directed towards an oxidized fragment of apolipoprotein B or an antibody fragment thereof, usable for therapeutical or prophylactic treatment of atherosclerosis by means of passive immunization.

There is provided the antibody directed towards the oxidized fragment of apolipoprotein B, wherein the oxidized fragment is IEIGLEGKGFEPTLEALFGK and the antibody or the antibody fragment includes a variable heavy chain region (VH) of a specific sequence and a variable light chain region (VL) of a specific sequence.


Inventors:
NILSSON JAN
CARLSSON ROLAND
BENGTSSON JENNY
STRANDBERG LEIF
Application Number:
JP2010001794A
Publication Date:
June 24, 2010
Filing Date:
January 07, 2010
Export Citation:
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Assignee:
BIOINVENT INTERNATL AB
International Classes:
A61K39/395; C12N15/09; A61P9/10; C07K14/775; C07K16/18; C12P21/08; C12Q1/04; C12Q1/68
Domestic Patent References:
JPH04159300A1992-06-02
Foreign References:
WO1999008109A21999-02-18
WO2001032070A22001-05-10
Attorney, Agent or Firm:
Masaaki Ogura