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Patent Searching and Data


Title:
【発明の名称】ハプテンで標識されたペプチド
Document Type and Number:
Japanese Patent JPH09500915
Kind Code:
A
Abstract:
PCT No. PCT/EP95/02921 Sec. 371 Date Jun. 13, 1996 Sec. 102(e) Date Jun. 13, 1996 PCT Filed Jul. 24, 1995 PCT Pub. No. WO96/03423 PCT Pub. Date Feb. 8, 1996The invention concerns a process for the production of hapten-labelled peptides which is characterized in that (a) a peptide with the desired amino acid sequence is synthesized on a solid phase from amino acid derivatives whose reactive side groups are blocked by protecting groups wherein the protecting groups on primary amino side groups are selected in such a way that, if desired, they can be selectively cleaved off, (b) protecting groups are cleaved to form at least one free primary amino group, (c) a hapten-active ester derivative is coupled to the at least one free primary amino group of the peptide and (d) if desired protecting groups that still remain are cleaved off, the hapten being selected from the group comprising sterols, bile acids, sexual hormones, corticoids, cardenolides, cardenolide-glycosides, bufadienolides, steroid-sapogenines and steroid alkaloids.

Inventors:
Hase, eva
Seidel, Christoph
Wienhus, Ursula-Henrike
Elf, Furts
Schmidt, Urban
Application Number:
JP50547195A
Publication Date:
January 28, 1997
Filing Date:
July 24, 1995
Export Citation:
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Assignee:
Boehringer Mannheim Gaem Behr
International Classes:
C07J17/00; C07K1/00; C07K1/04; C07K1/06; C07K1/107; C07K1/13; C07K7/06; G01N33/53; C07K7/08; C07K14/155; C07K14/16; C07K14/18; G01N33/531; G01N33/532; G01N33/533; G01N33/543; G01N33/68; G01N33/74; G01N33/92; (IPC1-7): C07K14/16; C07K1/04; C07K1/13; C07K14/155; C07K14/18; G01N33/532
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)