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Title:
PEPTIDE COMPOUND
Document Type and Number:
Japanese Patent JPS6363649
Kind Code:
A
Abstract:

NEW MATERIAL:The compound of formula I [R1 is -B-R7 (B is lower alkylene; R7 is aryl, etc.), etc., R2 is aryl or heteroaryl; R is H or lower alkyl; R3 is H, 1W10C alkyl, etc.; R4 is isopropyl, phenyl, etc.; R5 is 1W5C alkyl; R6 is substituted 1W10C alkyl, etc.].

EXAMPLE: Nα-[bis(1-naphthylmethyl)acetyl]-L-histidyl-statyl-L-leucyl--L-lysinol.

USE: A renin inhibitor useful as a diagnostic and remedy for hypertension.

PREPARATION: The compound of formula I can be produced by reacting the compound of formula II (R3a is R3 having protected amino, carboxy, etc., or same as R3) with the compound of formula III (R6a is R6 having protected amino, guanidyl, etc., or same as R6) and deprotecting the resultant product.


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Inventors:
MORISAWA YASUHIRO
YABE YUICHIRO
KATAOKA MITSURU
IIJIMA YASUTERU
TAKAHAGI HIDEKUNI
KOKUBU TATSURO
HIWADA KUNIO
Application Number:
JP20862186A
Publication Date:
March 22, 1988
Filing Date:
September 04, 1986
Export Citation:
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Assignee:
SANKYO CO
International Classes:
A61K38/00; A61P9/12; C07C67/00; C07C237/12; C07C237/22; C07C239/00; C07C271/08; C07C275/04; C07C279/08; C07C279/14; C07C301/00; C07C309/15; C07C313/00; C07C317/50; C07C323/52; C07C323/59; C07C323/60; C07C323/63; C07K5/06; C07K14/81; (IPC1-7): A61K37/02; C07C103/50; C07C103/76; C07C125/065; C07C127/15; C07C129/12; C07C143/155; C07C147/02; C07C147/14; C07C149/243; C07C149/273; C07C149/43; C07K5/06
Attorney, Agent or Firm:
Akio Ohno



 
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