Title:
PEPTIDE DERIVATIVE, MANUFACTURE AND RENNIN INHIBITOR
Document Type and Number:
Japanese Patent JPS6156194
Kind Code:
A
Abstract:
The compounds according to the invention correspond to the general formula: R1-Phe-R2-Sta-R3-Sta-R4 (I) in which statyl (Sta) is used to denote the radical derived from the amino acid statine, namely: 3S,4S isomer - R1 denotes a protective group for the amine functional group, such as an alkanoyl group and in particular the isovaleryl group, a phenylalkanoyl group, an aroyl group, an arylsulphonyl group, an arylalkylsulphonyl group or else a t-butoxycarbonyl (BOC) or benzyloxycarbonyl (Z) or adamantyloxycarbonyl (Adoc) group; - R2 denotes the radical derived from an amino acid chosen from leucine, norleucine, histidine and norvaline. - R3 denotes the radical derived from an amino acid chosen from alanine, leucine and isoleucine. - R4 is an amino group.e
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Inventors:
REMI GEGAN
JIYOSEFU DEIASU
JINO NISATO
PIEERU KORUBORU
JIYOSEFU DEIASU
JINO NISATO
PIEERU KORUBORU
Application Number:
JP11301585A
Publication Date:
March 20, 1986
Filing Date:
May 24, 1985
Export Citation:
Assignee:
SANOFI SA
INST NAT SANTE RECH MED
INST NAT SANTE RECH MED
International Classes:
C07K7/02; A61K38/00; A61K38/55; A61P9/12; A61P43/00; C07K1/113; C07K5/02; C07K14/81; C12N9/99; (IPC1-7): A61K37/02; A61K37/64; C07K7/02; C07K99/00; C12N9/99
Attorney, Agent or Firm:
Eiji Saegusa