Title:
ペプチド誘導体及びその薬学的に許容される塩、その製造方法並びにその用途
Document Type and Number:
Japanese Patent JP4601249
Kind Code:
B2
Abstract:
The present invention provides a peptide derivative of formula (I) wherein X is -CHOH- or -CO-; R1 and R2 are hydrogen or substituted oxycarbonyl; R3 is substituted oxycarbonyl; R4 is hydroxyl, lower alkoxy, optionally substituted piperazinyl or the like; R5 is a R-group side chain of an alpha-amino acid optionally protected by a protective group, R6 is hydroxyl, lower alkoxy or the like; m is 0 or 1; and n is an integer of 2 to 6; or a pharmaceutically acceptable salt thereof. The present invention further provides a production process and use thereof.
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Inventors:
Kenji Yamamoto
Etsuko Suda
Takuya Asao
Etsuko Suda
Takuya Asao
Application Number:
JP2002539311A
Publication Date:
December 22, 2010
Filing Date:
November 02, 2001
Export Citation:
Assignee:
Kyushu University
International Classes:
C07K5/023; A61K38/00; A61P1/02; A61P43/00; C07C269/04; C07C269/06; C07C271/22; C07D295/185; C07K5/072; C07K5/093; C12N9/99
Domestic Patent References:
| JP11228526A | ||||
| JP11258597A |
Foreign References:
| WO1998050420A1 |
Other References:
J.BIOCHEM.,2000,VOL.128,P.877-881
J.ENZYME INHIB.,1995,VOL.9,NO.1,P.43-60
BIOORG.MED.CHEM.,1995,VOL.3,NO.8,P.1063-1078
J.ENZYME INHIB.,1995,VOL.9,NO.1,P.43-60
BIOORG.MED.CHEM.,1995,VOL.3,NO.8,P.1063-1078
Attorney, Agent or Firm:
Eiji Saegusa
Mutsuko Nakano
Masahito Hayashi
Junya Tanaka
Mutsuko Nakano
Masahito Hayashi
Junya Tanaka