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Title:
PEPTIDE AND ITS SALT
Document Type and Number:
Japanese Patent JPH05140196
Kind Code:
A
Abstract:

PURPOSE: To provide a new peptide having a specific amino acid sequence, exhibiting specific reactivity and high binding property to diuretic hormone and useful as a detection reagent for diuretic hormone, a diagnostic agent for hypertension and a treating agent for suppressing and modifying the physiological function.

CONSTITUTION: The objective peptide containing a sequence of at least 4 consecutive amino acids existing in the amino acid sequence specified by formula I or formula II and bindable to diuretic hormone is produced by using an insoluble resin having functional groups as the solid-phase carrier for the solid-phase synthesis of peptide, bonding an amino acid having protected α-amino group and optionally side-chain functional group from the C-terminal side to the resin according to the amino acid sequence of the active part of an atrial natriuretic peptide receptor, removing the α-amino-protecting group, repeating the above operations to successively add the amino acids to synthesize a protected peptide resin and treating the resin with a trifluoroacetic acid solution, etc., to separate the peptide from the resin and remove all protecting groups from the peptide and finally purifying the product by high-performance liquid chromatography.


Inventors:
HAYASHI TAKASHI
WATANABE HIROO
IZUTSU HIROSHI
ODAKAWA YASUHISA
BABA KENZO
Application Number:
JP29571491A
Publication Date:
June 08, 1993
Filing Date:
November 12, 1991
Export Citation:
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Assignee:
HITACHI CHEMICAL CO LTD
International Classes:
A61K38/00; A61P9/12; C07K5/10; C07K7/06; G01N33/50; G01N33/53; G01N33/68; (IPC1-7): A61K37/02; C07K5/10; C07K7/06; C07K99/00; G01N33/50; G01N33/53; G01N33/68
Attorney, Agent or Firm:
Kunihiko Wakabayashi



 
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