Title:
ペプチド製造方法、及びベンジル化合物
Document Type and Number:
Japanese Patent JP7338088
Kind Code:
B2
Abstract:
One problem to be addressed by the present invention is to provide: a protecting group removing method capable of suppressing generation of double-hit bodies and diketopiperazine, easily scavenging a fulvene backbone-including compound that is a by-product potentially generated after deprotecting a protecting group having a fluorine backbone, and easily isolating a scavenged body of the by-product; a peptide production method comprising a step for removing a protecting group; and a protecting group removing agent. A peptide production method according to one aspect of the present invention comprises: a step for bringing, in an organic solvent, a scavenger represented by formula (Z1) into contact with an amino group-containing compound in which the N-terminal is protected by a protecting group having a fluorine backbone, to obtain a scavenged body in which the scavenger is bound to a by-product having a fulvene backbone derived from the protecting group; and a step for separating the obtained scavenged body from the organic solvent.
Inventors:
Munee Kasai
Yasushi Shimoda
Makoto Sato
Anri Uehara
Keisuke Matsuura
Yasushi Shimoda
Makoto Sato
Anri Uehara
Keisuke Matsuura
Application Number:
JP2023063078A
Publication Date:
September 04, 2023
Filing Date:
April 07, 2023
Export Citation:
Assignee:
Tokuyama Corporation
International Classes:
C07C43/23; C07K1/02; C07K1/06
Domestic Patent References:
| JP2014074020A |
Other References:
Polymer Chemistry,2014年,Vol.5, No.17,p.5147-5159
ACS NANO,2015年,Vol.9, No.3,p.3084-3096
ACS NANO,2015年,Vol.9, No.3,p.3084-3096
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK