Title:
C型肝炎ウィルスに対して細胞障害性Tリンパ球反応を誘発するペプチド
Document Type and Number:
Japanese Patent JP3844494
Kind Code:
B2
Abstract:
The present invention is directed to a molecule comprising a polypeptide having substantial homology with a CTL epitope selected from the group consisting of ADLMGYIPLV (Core131-140; SEQ ID NO:1), LLALLSCLTV (Core178-187; SEQ ID NO:2), QLRRHIDLLV (SEQ ID NO:55), LLCPAGHAV (NS31169-1177; SEQ ID NO:26), KLVALGINAV (NS31406-1415; SEQ ID NO:28), SLMAFTAAV (NS41789-1797; SEQ ID NO:34), LLFNILGGWV (NS41807-1816; SEQ ID NO:35), and ILDSFDPLV (NS52252-2260; SEQ ID NO:42). Such molecules are used for the treatment and prevention of acute or chronic HCV hepatitis; suitable pharmaceutical compositions and methods using such compositions are disclosed.
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Inventors:
Chisari, Francis, Buoy
Cerny, Andreas
Cerny, Andreas
Application Number:
JP52415195A
Publication Date:
November 15, 2006
Filing Date:
March 16, 1995
Export Citation:
Assignee:
THE SCRIPPS RESEARCH INSTITUTE
International Classes:
C07K14/18; C12Q1/02; A61K38/00; A61K39/29; A61K39/39; A61K47/48; A61P1/16; A61P31/12; A61P31/18; A61P37/04; C07K7/06; C07K7/08; C07K17/00; C12Q1/70; G01N33/53; G01N33/576; A61K39/00
Domestic Patent References:
| JP4504715A | ||||
| JP8507525A | ||||
| JP9504534A | ||||
| JP6199894A |
Foreign References:
| WO1993025575A1 |
Other References:
Proc.Natl.Acad.Sci.USA.,Vol.89,No.8(1992)p.3190-3194
J.Clin.Microbiol.,Vol.30,No.8(1992)p.1989-1994
J.Virol.,Vol.66,No.7(1992)p.4098-4106
J.Virol.,Vol.67,No.12(1993)p.7522-7532
Hepatology,Vol.18,No.5(1993)p.1039-1044
J.Cell.Biochem.,Suppl.17,Part.D(1993)p.64
J.Clin.Microbiol.,Vol.30,No.8(1992)p.1989-1994
J.Virol.,Vol.66,No.7(1992)p.4098-4106
J.Virol.,Vol.67,No.12(1993)p.7522-7532
Hepatology,Vol.18,No.5(1993)p.1039-1044
J.Cell.Biochem.,Suppl.17,Part.D(1993)p.64
Attorney, Agent or Firm:
Akitoshi Ota
Otawa Maki
Otawa Maki