Peptide which has a stable secondary structure, peptide libraries, those manufacturing methods

Japanese Patent JP6004399

B2

An object of the invention is to provide a peptide having a stabilized secondary structure. The present invention provides a peptide having a secondary structure stabilized by a crosslinked structure and containing at least one combination of a special amino acid of the formula (I): (wherein, (A) represents a single bond or a linking group having, in the main chain thereof, from 1 to 10 atoms; (B) represents a group containing at least one À bond; (C) represents a hydrogen atom or an alkyl group which may be substituted with a substituent; and X represents a group substitutable by a substitution reaction with a sulfanyl group) and an amino acid having, in the side chain thereof, a sulfanyl group; and having the crosslinked structure formed through a thioether bond between the side chain of the special amino acid residue and the sulfanyl group.

JPH0826065	[Title of Invention] New Antibiotic B-3543
JP7460700	Saposin lipoprotein particles and libraries from crude membranes
WO/1997/035194	ENANTIOMERIC SCREENING PROCESS, AND COMPOSITIONS THEREFOR

Hiroaki Suga
Higuchi

JP2012546968A

October 05, 2016

December 05, 2011

Click for automatic bibliography generation  

National University Corporation Tokyo University

C07K2/00; C12N15/09; C12P21/02; C40B40/10

JPN6015052744; Ｙｕｓｕｋｅ　Ｓａｋｏ　ｅｔ　ａｌ．: 'Ｒｉｂｏｓｏｍａｌ　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　Ｂｉｃｙｃｌｉｃ　Ｐｅｐｔｉｄｅｓ　ｖｉａ　Ｔｗｏ　Ｏｒｔｈｏｇｏｎａｌ　Ｉｎｔｅｒ-Ｓｉｄｅ-Ｃｈａｉｎ　Ｒｅａｃｔｉｏｎｓ' Ｊ．　Ａｍ．　Ｃｈｅｍ．　Ｓｏｃ． Ｖｏｌ．　１３０，　Ｎｏ．　２３, 2008, ｐ．　７２３２-７２３４
JPN6015052747; 特殊環状ペプチドの翻訳合成と医薬品探索への展開: '林　剛介　他' 生化学 第８２巻　第６号, 20100625, ｐ．　５０５-５１４
JPN6015052750; Ａ．　Ｃ．　Ａ．　Ｊａｎｓｅｎ　ｅｔ　ａｌ．: 'Ｓｔｕｄｉｅｓ　ｏｎ　ｐｏｌｙｐｅｐｔｉｄｅｓ．　Ｐａｒｔ　ＶＩＩ，　：　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ＤＬ-，　Ｌ-　ａｎｄ　Ｄ-２-ａｍｉｎｏ-６-ｄｉｍｅｔｈｙｌａｍｉｎｏ-４-ｈｅｘｙｎｏｉｃ　ａ' ＲＥＣＵＥＩＬ Ｖｏｌ．　８８，　Ｎｏ．　７, 1969, ｐ．　８１９-８２７

Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito

Previous Patent: Automatic analysis device

Next Patent: An advertising distribution system and an advertisement distribution method