PEPTIDES DERIVED FROM HUMAN BPLP PROTEIN, POLYNUCLEOTIDES ENCODING PEPTIDES, AND ANTIBODIES DIRECTED AGAINST PEPTIDES

Japanese Patent JP2014176383

A

PROBLEM TO BE SOLVED: To provide peptides derived from human BPLP protein, polynucleotides encoding the peptides, and antibodies directed against the peptides.SOLUTION: The invention relates to a peptide that is a maturation product of the basic proline-rich lacrimal protein (BPLP), or peptide derivatives or mimetics of the maturation product, wherein the peptide or peptide derivative exhibits an inhibitory property against a metallo-ectopeptidase, especially NEP and/or APN. The invention also relates to polynucleotides encoding the peptides and to antibodies directed against the peptides. Furthermore, the present invention relates to diagnostic and therapeutic uses of human BPLP protein and inhibitory peptides derived therefrom, polypeptides encoding human BPLP protein or peptides derived therefrom as well as antibodies directed against BPLP protein or peptides derived therefrom.

ROUGEOT CATHERINE
HUAULME JEAN-FANCOIS
UNGEHEUER MARIE-NOELLE
WISNER ANNE
DUFOUR EVELYNE

JP2014078577A

September 25, 2014

April 07, 2014

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PASTEUR INSTITUT

C12N15/09; A61K35/76; A61K38/00; A61K39/395; A61K48/00; A61P25/28; A61P29/00; A61P43/00; C07K5/083; C07K5/113; C07K7/06; C07K7/08; C07K14/435; C07K14/47; C07K14/81; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/15; G01N33/50; C12N9/99; C12Q1/02

JPN6009037736; 細胞の分子生物学 第９版, 19980710, ｐ．３２４-３２５, 株式会社　ニュートンプレス
JPN7010002586; ＤＩＣＫＩＮＳＯＮ，　Ｄ．Ｐ．　ａｎｄ　ＴＨＩＥＳＳＥ　Ｍ．: 'ｃＤＮＡ　ｃｌｏｎｉｎｇ　ｏｆ　ａｎ　ａｂｕｎｄａｎｔ　ｈｕｍａｎ　ｌａｃｒｉｍａｌ　ｇｌａｎｄ　ｍＲＮＡ　ｅｎｃｏｄｉｎｇ　ａ　ｎｏｖｅｌ　ｔｅａｒ　ｐｒｏｔｅｉｎ．' Ｃｕｒｒ．　Ｅｙｅ　Ｒｅｓ． Ｖｏｌ．１５　Ｎｏ．４, 1996, ｐ．３７７-３８６

Aoki 篤
Ishida 敬
Tsumoru Fukumoto
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei

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