Title:
アミロイド線維の形成を抑制するペプチド
Document Type and Number:
Japanese Patent JP7420361
Kind Code:
B2
Abstract:
To provide a peptide that can inhibit the formation of amyloid fibril.SOLUTION: A peptide is prepared that has an amino acid sequence with the number of amino acid residues of 7-20, and represented by the following formula (I): AXVXIXX(I) (where, A is alanine, V is valine, I is isoleucine, X, X, Xeach show a hydrophilic amino acid, Xis threonine or valine).SELECTED DRAWING: None
Inventors:
Masatoshi Saeki
Ikumi Shibatate
Ikumi Shibatate
Application Number:
JP2019031383A
Publication Date:
January 23, 2024
Filing Date:
February 25, 2019
Export Citation:
Assignee:
Sanyo Onoda City Yamaguchi Tokyo University of Science
International Classes:
A61K8/64; C07K7/06; A61P43/00; A61Q19/02; C07K7/08; G01N33/566
Foreign References:
| WO2018189152A2 | ||||
| WO2016172722A1 | ||||
| WO2009036246A2 |
Other References:
Giano M et al,Controlled Biodegradation of Self-Assembling β-hairpin Peptide Hydrogels by Proteolysis with Matrix Metalloproteinase-13,Biomaterials,32(27),2011年,6471-6477
Nagy K et al,Enhanced Mechanical Rigidity of Hydrogels Formed From Enantiomeric Peptide Assemblies,J Am Chem Soc,2011年,133 (38),14975-14977
Nagy K et al,Enhanced Mechanical Rigidity of Hydrogels Formed From Enantiomeric Peptide Assemblies,J Am Chem Soc,2011年,133 (38),14975-14977
Attorney, Agent or Firm:
Shohei Fujimoto