Title:
PEPTIDOMIMETIC MACROCYCLES
Document Type and Number:
Japanese Patent JP2019031494
Kind Code:
A
Abstract:
To provide p53-based peptidomimetic macrocycles that modulate the activity of p53 by inhibiting interactions between p53 and HDM2, p53 and HDMX, or p53 and both HDM2 and HDMX proteins, and that may be used for treating diseases including cancer and other hyperproliferative diseases.SOLUTION: Described herein are stably cross-linked peptides related to a portion of human p53. These cross-linked peptides contain at least two modified amino acids that together form an intramolecular cross-link that can help to stabilize the α-helical secondary structure of a portion of p53 that is thought to be important for binding of p53 to HDM2 and for binding of p53 to HDMX.SELECTED DRAWING: None
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Inventors:
VINCENT GUERLAVAIS
NORIYUKI KAWAHATA
NORIYUKI KAWAHATA
Application Number:
JP2018157596A
Publication Date:
February 28, 2019
Filing Date:
August 24, 2018
Export Citation:
Assignee:
AILERON THERAPEUTICS INC
International Classes:
C07K11/02; A61K38/10; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Takumi Terachi
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Takumi Terachi