Title:
経皮治療系
Document Type and Number:
Japanese Patent JP2004506682
Kind Code:
A
Abstract:
Use of a transdermal therapeutic system (TTS) comprising a pharmaceutical layer containing at least one matrix having an active ingredient and/or an active ingredient reservoir; a diffusion barrier that is permeable to said active ingredient and arranged on the skin side of the active ingredient reservoir; and an ergoline derivative or salt thereof as an active ingredient for producing an agent for obtaining and maintaining the circadian rhythm under dopamine therapy. The invention relates to the use of a transdermal therapeutic system (TTS) comprising a medicinal layer, which contains at least one matrix comprising an active ingredient and/or an active ingredient reservoir and a diffusion barrier situated on the skin side of the active ingredient reservoir and permeable to active ingredients, in addition to, an ergoline-derivative or physiologically compatible salt with an acid thereof, as an active ingredient, for producing a means for treating the restless-legs-syndrome. The invention relates to the use of a dopamine agonist in the form of an agent consisting of at least two spatially discrete compositions, of which one is a transdermal therapeutic system (TTS) containing the dopaminergic agent and another one or more are preparations for oral and/or parenteral application containing that same dopaminergic agent for the treatment of dopaminergically treatable diseases with the following elements: a) the TTS is continuously applied, b) within the duration of application in a) the composition for oral or parenteral dosage is administered. The invention concerns a transdermal therapeutic system containing ergoline derivatives, preferably lisuride, with a stabilized ergoline compound. Stabilization of the oxidation sensitive ergoline combination is done through a combination of at least one fat-soluble, radical-trapping antioxidant, preferably Di-tert.-butylmethylphenols, Di-tert.-butylmetoxyphenols, tocopherols or ubichinones and a basic polymer.
Inventors:
Binto-Hanke, Freight
Guyunter, Clemens
Horovsky, Reinhard
Tatsk, Johannes
Guyunter, Clemens
Horovsky, Reinhard
Tatsk, Johannes
Application Number:
JP2002520811A
Publication Date:
March 04, 2004
Filing Date:
August 24, 2001
Export Citation:
Assignee:
Nieurobiotech GMBH
International Classes:
C07D457/00; A61K9/70; A61K31/437; A61K31/48; A61K47/02; A61K47/04; A61K47/06; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/28; A61K47/30; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61L15/58; A61P5/08; A61P5/24; A61P13/02; A61P13/10; A61P15/00; A61P15/08; A61P15/14; A61P25/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P43/00; (IPC1-7): A61K31/48; A61K9/70; A61K47/02; A61K47/04; A61K47/06; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/28; A61K47/30; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61P13/02; A61P15/08; A61P15/14; A61P25/16; A61P25/18
Attorney, Agent or Firm:
Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki