To provide a stable osmotic agent in relation to a peritoneal dialysis and solution generally used in the same.

There is provided a peritoneal dialysis solution that contains heat stable osmotic agents (such as D-glucitols, gluconic acids and alkylglycosides produced by reduction, oxidation or glycosylation of icodextrins respectively). As a result, osmotic agents that are stable under autoclaving or heat sterilization conditions are provided which reduce the amount of bioincompatible materials in the sterilized peritoneal dialysis solution. Methods of preparing the D-glucitols, gluconic acids and alkylglycosides are disclosed.