Title:
PHARMACEUTICAL COMBINATION
Document Type and Number:
Japanese Patent JP2017071636
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide pharmaceutical combinations which are suitable for the treatment of a pain as an anti-epileptic and which preferably exhibit fewer undesired side effects compared to its individual components, if administered in effective doses.SOLUTION: A pharmaceutical combination comprises (a) 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol represented by formula (I), and (b) an anti-epileptic selected from pregabalin, gabapentin, topiramate, lamotrigine, carbamazepine, mexiletine, lacosamide, phenytoin, levetiracetam, retigabine, valproic acid and ralfinamide.SELECTED DRAWING: None
Inventors:
PETRA BLOMS-FUNKE
SCHIENE KLAUS
CHRISTOPH THOMAS
SCHIENE KLAUS
CHRISTOPH THOMAS
Application Number:
JP2016240032A
Publication Date:
April 13, 2017
Filing Date:
December 12, 2016
Export Citation:
Assignee:
GRUENENTHAL GMBH
International Classes:
A61K31/137; A61K31/138; A61K31/165; A61K31/19; A61K31/195; A61K31/197; A61K31/27; A61K31/4015; A61K31/4166; A61K31/522; A61K31/53; A61K31/55; A61K31/7048; A61K45/00; A61P25/04; A61P25/06; A61P25/08; A61P29/00; A61P43/00
Domestic Patent References:
| JP5731387B2 | 2015-06-10 |
Foreign References:
| WO2009067703A2 | 2009-05-28 | |||
| WO2007087452A2 | 2007-08-02 |
Other References:
リリカカプセル添付文書, JPN6015051241, 27 November 2015 (2015-11-27)
MARK,D. ET AL: "Nonsteroidal Anti-Inflammatory Drugs, Traditional Opioids, and Tramadol: Contrasting Therapies for t", CLINICAL THERAPEUTICS, vol. 19, no. 3, JPN6010073077, 1997, pages 420 - 432, XP000982708, DOI: doi:10.1016/S0149-2918(97)80127-0
MARK,D. ET AL: "Nonsteroidal Anti-Inflammatory Drugs, Traditional Opioids, and Tramadol: Contrasting Therapies for t", CLINICAL THERAPEUTICS, vol. 19, no. 3, JPN6010073077, 1997, pages 420 - 432, XP000982708, DOI: doi:10.1016/S0149-2918(97)80127-0
Attorney, Agent or Firm:
Mitsufumi Esaki
Blacksmith
Katsunori Uenishi
Blacksmith
Katsunori Uenishi
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