Title:
PHARMACEUTICAL COMPOSITION AQUEOUS SOLUTION OF PIROXICAM AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPH01299230
Kind Code:
A
Abstract:
PURPOSE: To prepare an aqueous solution of pharmaceutical composition, usable for injection or ophthalmic applications and having a high local tolerability by dispersing piroxicam which is a nonsteroidal antiinflammatory agent in water, adding an alkali(ne earth) metallic hydroxide thereto under stirring and completely dissolving the alkali(ne earth) metallic hydroxide therein. CONSTITUTION: Piroxicam [chemical name: N-(2-pyridyl)-2-methyl-4-hydroxy-2 H-1,2-benzothiazine-3-carboxamide 1,1-dioxide] is dispersed in water at a concentration within the range of 1-4wt./vol.% and an aqueous solution of an alkali(ne earth) metallic hydroxide, preferably a 1N NaOH in a stoichiometric amount is then added thereto under stirring and completely dissolved therein. The aqueous solution is in the form of a directly usable solution or a freeze-dried state for dissolving in distilled water for injection before use and contains 10-30mg active ingredient in a dose at a time or at 0.2-1% concentration of the active ingredient.
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Inventors:
PAORO KIEJI
RUCHIANA PABUESHI
RUCHIANA PABUESHI
Application Number:
JP7794989A
Publication Date:
December 04, 1989
Filing Date:
March 29, 1989
Export Citation:
Assignee:
CHIESI FARMA SPA
International Classes:
A61K9/00; A61K9/06; A61K31/54; A61K9/08; A61P29/00; (IPC1-7): A61K9/08; A61K31/54
Attorney, Agent or Firm:
Michiko Shinoda (1 outside)