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Title:
PHARMACEUTICAL COMPOSITION CONTAINING NITROGEN OXIDE RELEASING BIOPOLYMER
Document Type and Number:
Japanese Patent JP2005325144
Kind Code:
A
Abstract:

To obtain a nitrogen oxide-releasing composition that can concentrate the effect of nitrogen oxide release to an application site and can control the release of nitrogen oxide for effective medication.

A polymeric composition capable of releasing nitric oxide under physiological conditions contains a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N2O2- functional group. A pharmaceutical composition comprising the polymeric composition and methods for treating biological disorders in which dosing of nitric oxide becomes therapeutic are also provided.


Inventors:
SAAVEDRA JOSEPH E
KEEFER LARRY K
ROLLER PETER P
AKAMATSU MIKI
Application Number:
JP2005000236706
Publication Date:
November 24, 2005
Filing Date:
August 17, 2005
Export Citation:
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Assignee:
US GOVERNMENT (US)
International Classes:
A61K45/00; A61K31/401; A61K31/655; A61K31/70; A61K31/785; A61K31/787; A61K35/12; A61K38/00; A61K38/22; A61K39/395; A61K47/48; A61P1/00; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/08; A61P15/06; A61P15/10; A61P25/00; A61P35/00; A61P35/04; A61P37/00; A61P43/00; C07C291/08; C07D207/50; C07H21/02; C07H21/04; C07K1/107; C07K5/062; C07K5/097; C08F8/30; (IPC1-7): A61K45/00; A61K35/12; A61K38/22; A61K39/395; A61P9/10; A61P15/10; A61P43/00
Attorney, Agent or Firm:
Takashima Hajime